Therapeutic opportunities in Ewing sarcoma: EWS-FLI inhibition via LSD1 targeting

Ewing sarcoma is an aggressive primary pediatric bone tumor, often diagnosed in adolescents and young adults. A pathognomonic reciprocal chromosomal translocation results in a fusion gene coding for a protein which derives its N-terminus from a FUS/EWS/TAF15 (FET) protein family member, commonly EWS...

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Udgivet i:Oncotarget
Main Authors: Theisen, Emily R., Pishas, Kathleen I., Saund, Ranajeet S., Lessnick, Stephen L.
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Review
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4951237/
https://ncbi.nlm.nih.gov/pubmed/26848860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7124
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