Role for the EWS domain of EWS/FLI in binding GGAA-microsatellites required for Ewing sarcoma anchorage independent growth

Ewing sarcoma usually expresses the EWS/FLI fusion transcription factor oncoprotein. EWS/FLI regulates myriad genes required for Ewing sarcoma development. EWS/FLI binds GGAA-microsatellite sequences in vivo and in vitro. These sequences provide EWS/FLI-mediated activation to reporter constructs, su...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Johnson, Kirsten M., Mahler, Nathan R., Saund, Ranajeet S., Theisen, Emily R., Taslim, Cenny, Callender, Nathan W., Crow, Jesse C., Miller, Kyle R., Lessnick, Stephen L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2017
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5603999/
https://ncbi.nlm.nih.gov/pubmed/28847958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1701872114
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