EGR1 dysregulation defines an inflammatory and leukemic program in cell trajectory of human-aged hematopoietic stem cells (HSC)

BACKGROUND: During aging, hematopoietic stem cells (HSC) lose progressively both their self-renewal and differentiation potential. The precise molecular mechanisms of this phenomenon are not well established. To uncover the molecular events underlying this event, we have performed a bioinformatics a...

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Foilsithe in:Stem Cell Res Ther
Main Authors: Desterke, Christophe, Bennaceur-Griscelli, Annelise, Turhan, Ali G.
Formáid: Artigo
Teanga:Inglês
Foilsithe: BioMed Central 2021
Ábhair:
Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8296523/
https://ncbi.nlm.nih.gov/pubmed/34294125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-021-02498-0
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