Massively parallel in vivo CRISPR screening identifies RNF20/40 as epigenetic regulators of cardiomyocyte maturation

The forward genetic screen is a powerful, unbiased method to gain insights into biological processes, yet this approach has infrequently been used in vivo in mammals because of high resource demands. Here, we use in vivo somatic Cas9 mutagenesis to perform an in vivo forward genetic screen in mice t...

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Udgivet i:Nat Commun
Main Authors: VanDusen, Nathan J., Lee, Julianna Y., Gu, Weiliang, Butler, Catalina E., Sethi, Isha, Zheng, Yanjiang, King, Justin S., Zhou, Pingzhu, Suo, Shengbao, Guo, Yuxuan, Ma, Qing, Yuan, Guo-Cheng, Pu, William T.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8295283/
https://ncbi.nlm.nih.gov/pubmed/34290256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24743-z
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