Endothelial TRPV4 channels prevent tumor growth and metastasis via modulation of tumor angiogenesis and vascular integrity

Transient receptor potential vanilloid 4 (TRPV4) is a ubiquitously expressed polymodally activated ion channel. TRPV4 has been implicated in tumor progression; however, the cell-specific role of TRPV4 in tumor growth, angiogenesis and metastasis is unknown. Here, we generated endothelial-specific TR...

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Publié dans:Angiogenesis
Auteurs principaux: Kanugula, Anantha K., Adapala, Ravi K., Jamaiyar, Anurag, Lenkey, Nina, Guarino, Brianna D., Liedtke, Wolfgang, Yin, Liya, Paruchuri, Sailaja, Thodeti, Charles K.
Format: Artigo
Langue:Inglês
Publié: 2021
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8295186/
https://ncbi.nlm.nih.gov/pubmed/33656628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10456-021-09775-9
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