Extracellular Vesicles From Pathological Microenvironment Induce Endothelial Cell Transformation and Abnormal Angiogenesis via Modulation of TRPV4 Channels

The soluble and mechanical microenvironment surrounding endothelial cells influences and instructs them to form new blood vessels. The cells in the pathological tumor microenvironment release extracellular vesicles (EVs) for paracrine signaling. EVs have been shown to induce angiogenesis by communic...

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Detalhes bibliográficos
Publicado no:Front Cell Dev Biol
Main Authors: Guarino, Brianna D., Adapala, Ravi K., Kanugula, Anantha K., Lenkey, Nina M., Dougherty, Julie A., Paruchuri, Sailaja, Khan, Mahmood, Thodeti, Charles K.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Cell and Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6928002/
https://ncbi.nlm.nih.gov/pubmed/31921855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2019.00344
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