Extracellular Vesicles From Pathological Microenvironment Induce Endothelial Cell Transformation and Abnormal Angiogenesis via Modulation of TRPV4 Channels

The soluble and mechanical microenvironment surrounding endothelial cells influences and instructs them to form new blood vessels. The cells in the pathological tumor microenvironment release extracellular vesicles (EVs) for paracrine signaling. EVs have been shown to induce angiogenesis by communic...

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Udgivet i:Front Cell Dev Biol
Main Authors: Guarino, Brianna D., Adapala, Ravi K., Kanugula, Anantha K., Lenkey, Nina M., Dougherty, Julie A., Paruchuri, Sailaja, Khan, Mahmood, Thodeti, Charles K.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019
Fag:
Cell and Developmental Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6928002/
https://ncbi.nlm.nih.gov/pubmed/31921855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2019.00344
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