Overcoming of Microenvironment Protection on Primary Chronic Lymphocytic Leukemia Cells after Treatment with BTK and MDM2 Pharmacological Inhibitors

In B-chronic lymphocytic leukemia (B-CLL), the interaction between leukemic cells and the microenvironment promotes tumor cell survival. The Bruton’s tyrosine kinase (BTK) inhibitor ibrutinib is one of the first-in-class molecules for the treatment of B-CLL patients; however, the emerging mechanisms...

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Veröffentlicht in:Curr Oncol
Hauptverfasser: Rimondi, Erika, Melloni, Elisabetta, Romani, Arianna, Tisato, Veronica, Casciano, Fabio, Rigolin, Gian Matteo, Milani, Daniela, Celeghini, Claudio, Zauli, Giorgio, Secchiero, Paola, Voltan, Rebecca
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8293193/
https://ncbi.nlm.nih.gov/pubmed/34287267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/curroncol28040223
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