Combined liver–cytokine humanization comes to the rescue of circulating human red blood cells

In vivo models that recapitulate human erythropoiesis with persistence of circulating red blood cells (RBCs) have remained elusive. We report an immunodeficient murine model in which combined human liver and cytokine humanization confer enhanced human erythropoiesis and RBC survival in the circulati...

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Publicado no:Science
Main Authors: Song, Yuanbin, Shan, Liang, Gbyli, Rana, Liu, Wei, Strowig, Till, Patel, Amisha, Fu, Xiaoying, Wang, Xiaman, Xu, Mina L., Gao, Yimeng, Qin, Ashley, Bruscia, Emanuela M., Tebaldi, Toma, Biancon, Giulia, Mamillapalli, Padmavathi, Urbonas, David, Eynon, Elizabeth, Gonzalez, David G., Chen, Jie, Krause, Diane S., Alderman, Jonathan, Halene, Stephanie, Flavell, Richard A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8292008/
https://ncbi.nlm.nih.gov/pubmed/33674488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abe2485
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