m(6)A Modification Prevents Formation of Endogenous Double-Stranded RNAs and Deleterious Innate Immune Responses during Hematopoietic Development

N(6) methyladenosine (m(6)A) is the most abundant RNA modification, but little is known about its role in mammalian hematopoietic development. Here, we show that conditional deletion of the m(6)A writer METTL3 in murine fetal liver resulted in hematopoietic failure and perinatal lethality. Loss of M...

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Bibliografiset tiedot
Julkaisussa:Immunity
Päätekijät: Gao, Yimeng, Vasic, Radovan, Song, Yuanbin, Teng, Rhea, Liu, Chengyang, Gbyli, Rana, Biancon, Giulia, Nelakanti, Raman, Lobben, Kirsten, Kudo, Eriko, Liu, Wei, Ardasheva, Anastasia, Fu, Xiaoying, Wang, Xiaman, Joshi, Poorval, Lee, Veronica, Dura, Burak, Viero, Gabriella, Iwasaki, Akiko, Fan, Rong, Xiao, Andrew, Flavell, Richard A., Li, Hua-Bing, Tebaldi, Toma, Halene, Stephanie
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2020
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7408742/
https://ncbi.nlm.nih.gov/pubmed/32497523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2020.05.003
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