m(6)A Modification Prevents Formation of Endogenous Double-Stranded RNAs and Deleterious Innate Immune Responses during Hematopoietic Development

N(6) methyladenosine (m(6)A) is the most abundant RNA modification, but little is known about its role in mammalian hematopoietic development. Here, we show that conditional deletion of the m(6)A writer METTL3 in murine fetal liver resulted in hematopoietic failure and perinatal lethality. Loss of M...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Gao, Yimeng, Vasic, Radovan, Song, Yuanbin, Teng, Rhea, Liu, Chengyang, Gbyli, Rana, Biancon, Giulia, Nelakanti, Raman, Lobben, Kirsten, Kudo, Eriko, Liu, Wei, Ardasheva, Anastasia, Fu, Xiaoying, Wang, Xiaman, Joshi, Poorval, Lee, Veronica, Dura, Burak, Viero, Gabriella, Iwasaki, Akiko, Fan, Rong, Xiao, Andrew, Flavell, Richard A., Li, Hua-Bing, Tebaldi, Toma, Halene, Stephanie
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7408742/
https://ncbi.nlm.nih.gov/pubmed/32497523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2020.05.003
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados