α-Synuclein fibrils subvert lysosome structure and function for the propagation of protein misfolding between cells through tunneling nanotubes

The accumulation of α-synuclein (α-syn) aggregates in specific brain regions is a hallmark of synucleinopathies including Parkinson disease (PD). α-Syn aggregates propagate in a “prion-like” manner and can be transferred inside lysosomes to recipient cells through tunneling nanotubes (TNTs). However...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :PLoS Biol
Главные авторы: Dilsizoglu Senol, Aysegul, Samarani, Maura, Syan, Sylvie, Guardia, Carlos M., Nonaka, Takashi, Liv, Nalan, Latour-Lambert, Patricia, Hasegawa, Masato, Klumperman, Judith, Bonifacino, Juan S., Zurzolo, Chiara
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2021
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8291706/
https://ncbi.nlm.nih.gov/pubmed/34283825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3001287
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы