α-Synuclein fibrils subvert lysosome structure and function for the propagation of protein misfolding between cells through tunneling nanotubes

The accumulation of α-synuclein (α-syn) aggregates in specific brain regions is a hallmark of synucleinopathies including Parkinson disease (PD). α-Syn aggregates propagate in a “prion-like” manner and can be transferred inside lysosomes to recipient cells through tunneling nanotubes (TNTs). However...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:PLoS Biol
Egile Nagusiak: Dilsizoglu Senol, Aysegul, Samarani, Maura, Syan, Sylvie, Guardia, Carlos M., Nonaka, Takashi, Liv, Nalan, Latour-Lambert, Patricia, Hasegawa, Masato, Klumperman, Judith, Bonifacino, Juan S., Zurzolo, Chiara
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2021
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8291706/
https://ncbi.nlm.nih.gov/pubmed/34283825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3001287
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak