α-Synuclein fibrils subvert lysosome structure and function for the propagation of protein misfolding between cells through tunneling nanotubes

The accumulation of α-synuclein (α-syn) aggregates in specific brain regions is a hallmark of synucleinopathies including Parkinson disease (PD). α-Syn aggregates propagate in a “prion-like” manner and can be transferred inside lysosomes to recipient cells through tunneling nanotubes (TNTs). However...

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Udgivet i:PLoS Biol
Main Authors: Dilsizoglu Senol, Aysegul, Samarani, Maura, Syan, Sylvie, Guardia, Carlos M., Nonaka, Takashi, Liv, Nalan, Latour-Lambert, Patricia, Hasegawa, Masato, Klumperman, Judith, Bonifacino, Juan S., Zurzolo, Chiara
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8291706/
https://ncbi.nlm.nih.gov/pubmed/34283825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3001287
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