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Functional requirement of terminal inverted repeats for efficient ProtoRAG activity reveals the early evolution of V(D)J recombination

The discovery of ProtoRAG in amphioxus indicated that vertebrate RAG recombinases originated from an ancient transposon. However, the sequences of ProtoRAG terminal inverted repeats (TIRs) were obviously dissimilar to the consensus sequence of mouse 12/23RSS and recombination mediated by ProtoRAG or...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Natl Sci Rev
Prif Awduron: Tao, Xin, Yuan, Shaochun, Chen, Fan, Gao, Xiaoman, Wang, Xinli, Yu, Wenjuan, Liu, Song, Huang, Ziwen, Chen, Shangwu, Xu, Anlong
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8289069/
https://ncbi.nlm.nih.gov/pubmed/34692056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nsr/nwz179
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