Quinazolin-derived myeloperoxidase inhibitor suppresses influenza A virus-induced reactive oxygen species, pro-inflammatory mediators and improves cell survival

Superoxide radicals and other reactive oxygen species (ROS) are implicated in influenza A virus-induced inflammation. In this in vitro study, we evaluated the effects of TG6-44, a novel quinazolin-derived myeloperoxidase-specific ROS inhibitor, on influenza A virus (A/X31) infection using THP-1 lung...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: De La Cruz, Juan A., Ganesh, Thota, Diebold, Becky A., Cao, Weiping, Hofstetter, Amelia, Singh, Neetu, Kumar, Amrita, McCoy, James, Ranjan, Priya, Smith, Susan M. E., Sambhara, Suryaprakash, Lambeth, J. David, Gangappa, Shivaprakash
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8289044/
https://ncbi.nlm.nih.gov/pubmed/34280220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0254632
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