Quinazolin-derived myeloperoxidase inhibitor suppresses influenza A virus-induced reactive oxygen species, pro-inflammatory mediators and improves cell survival

Superoxide radicals and other reactive oxygen species (ROS) are implicated in influenza A virus-induced inflammation. In this in vitro study, we evaluated the effects of TG6-44, a novel quinazolin-derived myeloperoxidase-specific ROS inhibitor, on influenza A virus (A/X31) infection using THP-1 lung...

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Detaylı Bibliyografya
Yayımlandı:PLoS One
Asıl Yazarlar: De La Cruz, Juan A., Ganesh, Thota, Diebold, Becky A., Cao, Weiping, Hofstetter, Amelia, Singh, Neetu, Kumar, Amrita, McCoy, James, Ranjan, Priya, Smith, Susan M. E., Sambhara, Suryaprakash, Lambeth, J. David, Gangappa, Shivaprakash
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2021
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8289044/
https://ncbi.nlm.nih.gov/pubmed/34280220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0254632
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