Quinazolin-derived myeloperoxidase inhibitor suppresses influenza A virus-induced reactive oxygen species, pro-inflammatory mediators and improves cell survival

Superoxide radicals and other reactive oxygen species (ROS) are implicated in influenza A virus-induced inflammation. In this in vitro study, we evaluated the effects of TG6-44, a novel quinazolin-derived myeloperoxidase-specific ROS inhibitor, on influenza A virus (A/X31) infection using THP-1 lung...

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Dettagli Bibliografici
Pubblicato in:PLoS One
Autori principali: De La Cruz, Juan A., Ganesh, Thota, Diebold, Becky A., Cao, Weiping, Hofstetter, Amelia, Singh, Neetu, Kumar, Amrita, McCoy, James, Ranjan, Priya, Smith, Susan M. E., Sambhara, Suryaprakash, Lambeth, J. David, Gangappa, Shivaprakash
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2021
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8289044/
https://ncbi.nlm.nih.gov/pubmed/34280220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0254632
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