Impact of the interplay between stemness features, p53 and pol iota on replication pathway choices

Using human embryonic, adult and cancer stem cells/stem cell-like cells (SCs), we demonstrate that DNA replication speed differs in SCs and their differentiated counterparts. While SCs decelerate DNA replication, differentiated cells synthesize DNA faster and accumulate DNA damage. Notably, both rep...

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Библиографические подробности
Опубликовано в: :Nucleic Acids Res
Главные авторы: Ihle, Michaela, Biber, Stephanie, Schroeder, Insa S, Blattner, Christine, Deniz, Miriam, Damia, Giovanna, Gottifredi, Vanesa, Wiesmüller, Lisa
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2021
Предметы:
Genome Integrity, Repair and Replication
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8287946/
https://ncbi.nlm.nih.gov/pubmed/34165573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab526
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