Impact of the interplay between stemness features, p53 and pol iota on replication pathway choices

Using human embryonic, adult and cancer stem cells/stem cell-like cells (SCs), we demonstrate that DNA replication speed differs in SCs and their differentiated counterparts. While SCs decelerate DNA replication, differentiated cells synthesize DNA faster and accumulate DNA damage. Notably, both rep...

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Dettagli Bibliografici
Pubblicato in:Nucleic Acids Res
Autori principali: Ihle, Michaela, Biber, Stephanie, Schroeder, Insa S, Blattner, Christine, Deniz, Miriam, Damia, Giovanna, Gottifredi, Vanesa, Wiesmüller, Lisa
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2021
Soggetti:
Genome Integrity, Repair and Replication
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8287946/
https://ncbi.nlm.nih.gov/pubmed/34165573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab526
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