Impact of the interplay between stemness features, p53 and pol iota on replication pathway choices

Using human embryonic, adult and cancer stem cells/stem cell-like cells (SCs), we demonstrate that DNA replication speed differs in SCs and their differentiated counterparts. While SCs decelerate DNA replication, differentiated cells synthesize DNA faster and accumulate DNA damage. Notably, both rep...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Ihle, Michaela, Biber, Stephanie, Schroeder, Insa S, Blattner, Christine, Deniz, Miriam, Damia, Giovanna, Gottifredi, Vanesa, Wiesmüller, Lisa
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2021
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8287946/
https://ncbi.nlm.nih.gov/pubmed/34165573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab526
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados