Intrathymic AAV gene transfer rapidly restores thymic function and long-term persistence of gene-corrected T cells

BACKGROUND: Patients with T cell immunodeficiencies are generally treated by allogeneic hematopoietic stem cell transplantation but alternatives are needed for patients without matched donors. An innovative intrathymic (IT) gene therapy approach, directly targeting the thymus, may improve outcome. O...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Izdano u:J Allergy Clin Immunol
Glavni autori: Pouzolles, Marie, Machado, Alice, Guilbaud, Mickaël, Irla, Magali, Gailhac, Sarah, Barennes, Pierre, Cesana, Daniela, Calabria, Andrea, Benedicenti, Fabrizio, Sergé, Arnauld, Raman, Indu, Li, Quan-Zhen, Montini, Eugenio, Klatzmann, David, Adjali, Oumeya, Taylor, Naomi, Zimmermann, Valérie S.
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8287836/
https://ncbi.nlm.nih.gov/pubmed/31513879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2019.08.029
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items