Efficient Intrathymic Gene Transfer Following In Situ Administration of a rAAV Serotype 8 Vector in Mice and Nonhuman Primates

The thymus is the primary site of T-cell development and plays a key role in the induction of self-tolerance. We previously showed that the intrathymic (IT) injection of a transgene-expressing lentiviral vector (LV) in mice can result in the correction of a T cell–specific genetic defect. Neverthele...

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Détails bibliographiques
Auteurs principaux: Moreau, Aurélie, Vicente, Rita, Dubreil, Laurence, Adjali, Oumeya, Podevin, Guillaume, Jacquet, Chantal, Deschamps, Jack Yves, Klatzmann, David, Cherel, Yan, Taylor, Naomi, Moullier, Philippe, Zimmermann, Valérie S
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2008
Sujets:
Original Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835094/
https://ncbi.nlm.nih.gov/pubmed/19088703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2008.272
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