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Pharmacological Inhibition of HSP90 Radiosensitizes Head and Neck Squamous Cell Carcinoma Xenograft by Inhibition of DNA Damage Repair, Nucleotide Metabolism, and Radiation-Induced Tumor Vasculogenesis

PURPOSE: Recent preclinical studies suggest combining the HSP90 inhibitor AT13387 (Onalespib) with radiation (IR) against colon cancer and head and neck squamous cell carcinoma (HNSCC). These studies emphasized that AT13387 downregulates HSP90 client proteins involved in oncogenic signaling and DNA...

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書誌詳細
出版年:Int J Radiat Oncol Biol Phys
主要な著者: Naz, Sarwat, Leiker, Andrew J., Choudhuri, Rajani, Preston, Olivia, Sowers, Anastasia L., Gohain, Sangeeta, Gamson, Janet, Mathias, Askale, Van Waes, Carter, Cook, John A., Mitchell, James B.
フォーマット: Artigo
言語:Inglês
出版事項: 2021
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC8286306/
https://ncbi.nlm.nih.gov/pubmed/33838214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijrobp.2021.03.048
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