Pharmacological Inhibition of HSP90 Radiosensitizes Head and Neck Squamous Cell Carcinoma Xenograft by Inhibition of DNA Damage Repair, Nucleotide Metabolism, and Radiation-Induced Tumor Vasculogenesis

PURPOSE: Recent preclinical studies suggest combining the HSP90 inhibitor AT13387 (Onalespib) with radiation (IR) against colon cancer and head and neck squamous cell carcinoma (HNSCC). These studies emphasized that AT13387 downregulates HSP90 client proteins involved in oncogenic signaling and DNA...

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Detalhes bibliográficos
Publicado no:Int J Radiat Oncol Biol Phys
Main Authors: Naz, Sarwat, Leiker, Andrew J., Choudhuri, Rajani, Preston, Olivia, Sowers, Anastasia L., Gohain, Sangeeta, Gamson, Janet, Mathias, Askale, Van Waes, Carter, Cook, John A., Mitchell, James B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8286306/
https://ncbi.nlm.nih.gov/pubmed/33838214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijrobp.2021.03.048
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