Abemaciclib, a Selective CDK4/6 Inhibitor Enhances the Radiosensitivity of Non-Small Cell Lung Cancer in vitro and in vivo

PURPOSE: To characterize the ionizing radiation (IR) enhancing effects and underlying mechanisms of CDK4/6 inhibitor, Abemaciclib in Non–Small Cell Lung Cancer cells (NSCLC) in vitro and in vivo. EXPERIMENTAL DESIGN: IR enhancement by Abemaciclib in a variety of NSCLC cell lines was assessed by in v...

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Veröffentlicht in:Clin Cancer Res
Hauptverfasser: Naz, Sarwat, Sowers, Anastasia, Choudhuri, Rajani, Wissler, Maria, Gamson, Janet, Mathias, Askale, Cook, John A., Mitchell, James B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6137329/
https://ncbi.nlm.nih.gov/pubmed/29716919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-3575
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