In Vitro and In Vivo Radiation Sensitization of Human Tumor Cells by a Novel Checkpoint Kinase Inhibitor, AZD7762

PURPOSE: Inhibition of checkpoint kinase 1 (Chk1) has been shown to enhance the cytotoxicity of DNA damaging targeted chemotherapy through cell cycle checkpoint abrogation and impaired DNA damage repair. A novel Chk1/2 inhibitor, AZD7762 was evaluated for potential enhancement of radiosensitivity fo...

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Bibliographic Details
Main Authors: Mitchell, James B., Choudhuri, Rajani, Fabre, Kristin, Sowers, Anastasia L., Citrin, Deborah, Zabludoff, Sonya D., Cook, John A.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2851146/
https://ncbi.nlm.nih.gov/pubmed/20233881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-3277
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