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In Vitro and In Vivo Radiation Sensitization of Human Tumor Cells by a Novel Checkpoint Kinase Inhibitor, AZD7762
PURPOSE: Inhibition of checkpoint kinase 1 (Chk1) has been shown to enhance the cytotoxicity of DNA damaging targeted chemotherapy through cell cycle checkpoint abrogation and impaired DNA damage repair. A novel Chk1/2 inhibitor, AZD7762 was evaluated for potential enhancement of radiosensitivity fo...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2851146/ https://ncbi.nlm.nih.gov/pubmed/20233881 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-3277 |
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