Inhibition of HSP90 as a Strategy to Radiosensitize Glioblastoma: Targeting the DNA Damage Response and Beyond

Radiotherapy is an essential component of multi-modality treatment of glioblastoma (GBM). However, treatment failure and recurrence are frequent and give rise to the dismal prognosis of this aggressive type of primary brain tumor. A high level of inherent treatment resistance is considered to be the...

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Veröffentlicht in:Front Oncol
Hauptverfasser: Orth, Michael, Albrecht, Valerie, Seidl, Karin, Kinzel, Linda, Unger, Kristian, Hess, Julia, Kreutzer, Lisa, Sun, Na, Stegen, Benjamin, Nieto, Alexander, Maas, Jessica, Winssinger, Nicolas, Friedl, Anna A., Walch, Axel K., Belka, Claus, Zitzelsberger, Horst, Niyazi, Maximilian, Lauber, Kirsten
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2021
Schlagworte:
Oncology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8011354/
https://ncbi.nlm.nih.gov/pubmed/33816244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2021.612354
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