A novel HSP90 inhibitor with reduced hepatotoxicity synergizes with radiotherapy to induce apoptosis, abrogate clonogenic survival, and improve tumor control in models of colorectal cancer

The chaperone heat shock protein 90 (HSP90) crucially supports the maturation, folding, and stability of a variety of client proteins which are of pivotal importance for the survival and proliferation of cancer cells. Consequently, targeting of HSP90 has emerged as an attractive strategy of anti-can...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Kinzel, Linda, Ernst, Anne, Orth, Michael, Albrecht, Valerie, Hennel, Roman, Brix, Nikko, Frey, Benjamin, Gaipl, Udo S., Zuchtriegel, Gabriele, Reichel, Christoph A., Blutke, Andreas, Schilling, Daniela, Multhoff, Gabriele, Li, Minglun, Niyazi, Maximilian, Friedl, Anna A., Winssinger, Nicolas, Belka, Claus, Lauber, Kirsten
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2016
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5190018/
https://ncbi.nlm.nih.gov/pubmed/27259245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9774
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires