A novel HSP90 inhibitor with reduced hepatotoxicity synergizes with radiotherapy to induce apoptosis, abrogate clonogenic survival, and improve tumor control in models of colorectal cancer

The chaperone heat shock protein 90 (HSP90) crucially supports the maturation, folding, and stability of a variety of client proteins which are of pivotal importance for the survival and proliferation of cancer cells. Consequently, targeting of HSP90 has emerged as an attractive strategy of anti-can...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Kinzel, Linda, Ernst, Anne, Orth, Michael, Albrecht, Valerie, Hennel, Roman, Brix, Nikko, Frey, Benjamin, Gaipl, Udo S., Zuchtriegel, Gabriele, Reichel, Christoph A., Blutke, Andreas, Schilling, Daniela, Multhoff, Gabriele, Li, Minglun, Niyazi, Maximilian, Friedl, Anna A., Winssinger, Nicolas, Belka, Claus, Lauber, Kirsten
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5190018/
https://ncbi.nlm.nih.gov/pubmed/27259245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9774
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