Proton-gated coincidence detection is a common feature of GPCR signaling

The evolutionary expansion of G protein-coupled receptors (GPCRs) has produced a rich diversity of transmembrane sensors for many physical and chemical signals. In humans alone, over 800 GPCRs detect stimuli such as light, hormones, and metabolites to guide cellular decision-making primarily using i...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Kapolka, Nicholas J., Rowe, Jacob B., Taghon, Geoffrey J., Morgan, William M., O’Shea, Corin R., Isom, Daniel G.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2021
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8285908/
https://ncbi.nlm.nih.gov/pubmed/34260394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2100171118
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