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The evolution and mechanism of GPCR proton sensing
Of the 800 G protein–coupled receptors (GPCRs) in humans, only three (GPR4, GPR65, and GPR68) regulate signaling in acidified microenvironments by sensing protons (H(+)). How these receptors have uniquely obtained this ability is unknown. Here, we show these receptors evolved the capability to sense...
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| Veröffentlicht in: | J Biol Chem |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7948426/ https://ncbi.nlm.nih.gov/pubmed/33478938 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.016352 |
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