Hypoimmune induced pluripotent stem cell–derived cell therapeutics treat cardiovascular and pulmonary diseases in immunocompetent allogeneic mice

The emerging field of regenerative cell therapy is still limited by the few cell types that can reliably be differentiated from pluripotent stem cells and by the immune hurdle of commercially scalable allogeneic cell therapeutics. Here, we show that gene-edited, immune-evasive cell grafts can surviv...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Deuse, Tobias, Tediashvili, Grigol, Hu, Xiaomeng, Gravina, Alessia, Tamenang, Annika, Wang, Dong, Connolly, Andrew, Mueller, Christian, Mallavia, Beñat, Looney, Mark R., Alawi, Malik, Lanier, Lewis L., Schrepfer, Sonja
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2021
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8285900/
https://ncbi.nlm.nih.gov/pubmed/34244428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2022091118
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