Hypoimmune induced pluripotent stem cell–derived cell therapeutics treat cardiovascular and pulmonary diseases in immunocompetent allogeneic mice

The emerging field of regenerative cell therapy is still limited by the few cell types that can reliably be differentiated from pluripotent stem cells and by the immune hurdle of commercially scalable allogeneic cell therapeutics. Here, we show that gene-edited, immune-evasive cell grafts can surviv...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Deuse, Tobias, Tediashvili, Grigol, Hu, Xiaomeng, Gravina, Alessia, Tamenang, Annika, Wang, Dong, Connolly, Andrew, Mueller, Christian, Mallavia, Beñat, Looney, Mark R., Alawi, Malik, Lanier, Lewis L., Schrepfer, Sonja
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8285900/
https://ncbi.nlm.nih.gov/pubmed/34244428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2022091118
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