Reduced glucose-stimulated insulin secretion following a 1-wk IGF-1 infusion in late gestation fetal sheep is due to an intrinsic islet defect

Insulin and insulin-like growth factor-1 (IGF-1) are fetal hormones critical to establishing normal fetal growth. Experimentally elevated IGF-1 concentrations during late gestation increase fetal weight but lower fetal plasma insulin concentrations. We therefore hypothesized that infusion of an IGF-...

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Publicado en:Am J Physiol Endocrinol Metab
Autores principales: White, Alicia, Stremming, Jane, Boehmer, Brit H., Chang, Eileen I., Jonker, Sonnet S., Wesolowski, Stephanie R., Brown, Laura D., Rozance, Paul. J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2021
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8285601/
https://ncbi.nlm.nih.gov/pubmed/33938236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00623.2020
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