Tetrasubstituted imidazoles as incognito Toll-like receptor 8 a(nta)gonists

Small-molecule modulators of TLR8 have drawn much interests as it plays pivotal roles in the innate immune response to single-stranded RNAs (ssRNAs) derived from viruses. However, their clinical uses are limited because they can invoke an uncontrolled, global inflammatory response. The efforts descr...

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Publicat a:Nat Commun
Autors principals: Yang, Yi, Csakai, Adam, Jiang, Shuangshuang, Smith, Christina, Tanji, Hiromi, Huang, Jian, Jones, Torey, Sakaniwa, Kentaro, Broadwell, Lindsey, Shi, Chengrui, Soti, Subada, Ohto, Umeharu, Fang, Yaohui, Shen, Shu, Deng, Fei, Shimizu, Toshiyuki, Yin, Hang
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8285539/
https://ncbi.nlm.nih.gov/pubmed/34272380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24536-4
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