USP29-mediated HIF1α stabilization is associated with Sorafenib resistance of hepatocellular carcinoma cells by upregulating glycolysis

Understanding the mechanisms underlying evasive resistance in cancer is an unmet medical need to improve the efficacy of current therapies. In hepatocellular carcinoma (HCC), aberrant expression of hypoxia-inducible factor 1 α (HIF1α) and increased aerobic glycolysis metabolism are drivers of resist...

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Detaylı Bibliyografya
Yayımlandı:Oncogenesis
Asıl Yazarlar: Gao, Ruize, Buechel, David, Kalathur, Ravi K. R., Morini, Marco F., Coto-Llerena, Mairene, Ercan, Caner, Piscuoglio, Salvatore, Chen, Qian, Blumer, Tanja, Wang, Xueya, Dazert, Eva, Heim, Markus H., Hall, Michael N., Tang, Fengyuan, Christofori, Gerhard
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2021
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8285469/
https://ncbi.nlm.nih.gov/pubmed/34272356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41389-021-00338-7
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