USP29-mediated HIF1α stabilization is associated with Sorafenib resistance of hepatocellular carcinoma cells by upregulating glycolysis

Understanding the mechanisms underlying evasive resistance in cancer is an unmet medical need to improve the efficacy of current therapies. In hepatocellular carcinoma (HCC), aberrant expression of hypoxia-inducible factor 1 α (HIF1α) and increased aerobic glycolysis metabolism are drivers of resist...

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Publicado no:Oncogenesis
Main Authors: Gao, Ruize, Buechel, David, Kalathur, Ravi K. R., Morini, Marco F., Coto-Llerena, Mairene, Ercan, Caner, Piscuoglio, Salvatore, Chen, Qian, Blumer, Tanja, Wang, Xueya, Dazert, Eva, Heim, Markus H., Hall, Michael N., Tang, Fengyuan, Christofori, Gerhard
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8285469/
https://ncbi.nlm.nih.gov/pubmed/34272356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41389-021-00338-7
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