The multikinase inhibitor Sorafenib enhances glycolysis and synergizes with glycolysis blockade for cancer cell killing

Although the only effective drug against primary hepatocarcinoma, the multikinase inhibitor Sorafenib (SFB) usually fails to eradicate liver cancer. Since SFB targets mitochondria, cell metabolic reprogramming may underlie intrinsic tumor resistance. To characterize cancer cell metabolic response to...

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Udgivet i:Sci Rep
Main Authors: Tesori, Valentina, Piscaglia, Anna Chiara, Samengo, Daniela, Barba, Marta, Bernardini, Camilla, Scatena, Roberto, Pontoglio, Alessandro, Castellini, Laura, Spelbrink, Johannes N., Maulucci, Giuseppe, Puglisi, Maria Ausiliatrice, Pani, Giovambattista, Gasbarrini, Antonio
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4361992/
https://ncbi.nlm.nih.gov/pubmed/25779766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep09149
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