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SOCS1 is an inducible negative regulator of interferon λ (IFN-λ)–induced gene expression in vivo
Type I (α and β) and type III (λ) IFNs are induced upon viral infection through host sensory pathways that activate IFN regulatory factors (IRFs) and nuclear factor κB. Secreted IFNs induce autocrine and paracrine signaling through the JAK-STAT pathway, leading to the transcriptional induction of hu...
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| Publicado no: | J Biol Chem |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5663890/ https://ncbi.nlm.nih.gov/pubmed/28900038 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.788877 |
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