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SOCS1 is an inducible negative regulator of interferon λ (IFN-λ)–induced gene expression in vivo

Type I (α and β) and type III (λ) IFNs are induced upon viral infection through host sensory pathways that activate IFN regulatory factors (IRFs) and nuclear factor κB. Secreted IFNs induce autocrine and paracrine signaling through the JAK-STAT pathway, leading to the transcriptional induction of hu...

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Podrobná bibliografie
Vydáno v:J Biol Chem
Hlavní autoři: Blumer, Tanja, Coto-Llerena, Mairene, Duong, Francois H. T., Heim, Markus H.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5663890/
https://ncbi.nlm.nih.gov/pubmed/28900038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.788877
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