Comprehensive functional evaluation of variants of fibroblast growth factor receptor genes in cancer

Various genetic alterations of the fibroblast growth factor receptor (FGFR) family have been detected across a wide range of cancers. However, inhibition of FGFR signaling by kinase inhibitors demonstrated limited clinical effectiveness. Herein, we evaluated the transforming activity and sensitivity...

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Udgivet i:NPJ Precis Oncol
Main Authors: Nakamura, Ikuko Takeda, Kohsaka, Shinji, Ikegami, Masachika, Ikeuchi, Hiroshi, Ueno, Toshihide, Li, Kunhua, Beyett, Tyler S., Koyama, Takafumi, Shimizu, Toshio, Yamamoto, Noboru, Takahashi, Fumiyuki, Takahashi, Kazuhisa, Eck, Michael J., Mano, Hiroyuki
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8285406/
https://ncbi.nlm.nih.gov/pubmed/34272467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41698-021-00204-0
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