Comprehensive functional evaluation of variants of fibroblast growth factor receptor genes in cancer

Various genetic alterations of the fibroblast growth factor receptor (FGFR) family have been detected across a wide range of cancers. However, inhibition of FGFR signaling by kinase inhibitors demonstrated limited clinical effectiveness. Herein, we evaluated the transforming activity and sensitivity...

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Gepubliceerd in:NPJ Precis Oncol
Hoofdauteurs: Nakamura, Ikuko Takeda, Kohsaka, Shinji, Ikegami, Masachika, Ikeuchi, Hiroshi, Ueno, Toshihide, Li, Kunhua, Beyett, Tyler S., Koyama, Takafumi, Shimizu, Toshio, Yamamoto, Noboru, Takahashi, Fumiyuki, Takahashi, Kazuhisa, Eck, Michael J., Mano, Hiroyuki
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2021
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8285406/
https://ncbi.nlm.nih.gov/pubmed/34272467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41698-021-00204-0
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