Enantioselective Iridium-Catalyzed Allylation of Nitroalkanes: Entry to β-Stereogenic α-Quaternary Primary Amines

The first systematic study of simple nitronate nucleophiles in iridium-catalyzed allylic alkylation are described. Using a tol-BINAP-modified π-allyliridium C,O-benzoate catalyst, α,α-disubstituted nitronates substitute racemic branched alkyl-substituted allylic acetates, thus providing entry to β-s...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Jung, Woo-Ok, Mai, Binh Khanh, Spinello, Brian J., Dubey, Zachary J., Kim, Seung Wook, Stivala, Craig E., Zbieg, Jason R., Liu, Peng, Krische, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8284932/
https://ncbi.nlm.nih.gov/pubmed/34152145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.1c05212
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