Hydroamination versus Allylic Amination in Iridium Catalyzed Reactions of Allylic Acetates with Amines: 1,3-Aminoalcohols via Ester-Directed Regioselectivity

In the presence of a neutral dppf-modified iridium catalyst and Cs(2)CO(3), linear allylic acetates react with primary amines to form products of hydroamination with complete 1,3-regioselectivity. The collective data, including deuterium labeling studies, corroborate a catalytic mechanism involving...

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Bibliografische gegevens
Gepubliceerd in:J Am Chem Soc
Hoofdauteurs: Kim, Seung Wook, Wurm, Thomas, Brito, Gilmar A., Jung, Woo-Ok, Zbieg, Jason R., Stivala, Craig E., Krische, Michael J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6264884/
https://ncbi.nlm.nih.gov/pubmed/29989803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b05683
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