Expression of the cancer-associated DNA polymerase ε P286R in fission yeast leads to translesion synthesis polymerase dependent hypermutation and defective DNA replication

Somatic and germline mutations in the proofreading domain of the replicative DNA polymerase ε (POLE-exonuclease domain mutations, POLE-EDMs) are frequently found in colorectal and endometrial cancers and, occasionally, in other tumours. POLE-associated cancers typically display hypermutation, and a...

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Foilsithe in:PLoS Genet
Main Authors: Soriano, Ignacio, Vazquez, Enrique, De Leon, Nagore, Bertrand, Sibyl, Heitzer, Ellen, Toumazou, Sophia, Bo, Zhihan, Palles, Claire, Pai, Chen-Chun, Humphrey, Timothy C., Tomlinson, Ian, Cotterill, Sue, Kearsey, Stephen E.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2021
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8284607/
https://ncbi.nlm.nih.gov/pubmed/34228709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1009526
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