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Drivers of Hsp104 potentiation revealed by scanning mutagenesis of the middle domain
Hsp104, a yeast protein disaggregase, can be potentiated via numerous missense mutations at disparate locations throughout the coiled‐coil middle domain (MD). Potentiated Hsp104 variants can counter the toxicity and misfolding of TDP‐43, FUS, and α‐synuclein, proteins which are implicated in neurode...
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| Udgivet i: | Protein Sci |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
John Wiley & Sons, Inc.
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8284572/ https://ncbi.nlm.nih.gov/pubmed/34010483 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.4126 |
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