A PEPTIDE-BASED CHECKPOINT IMMUNOMODULATOR ALLEVIATES IMMUNE DYSFUNCTION IN MURINE POLYMICROBIAL SEPSIS

Sepsis-induced immunosuppression involves both innate and adaptive immunity and is associated with the increased expression of checkpoint inhibitors, such as programmed cell-death protein 1 (PD-1). The expression of PD-1 is associated with poor outcomes in septic patients, and in models of sepsis, b...

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Detalhes bibliográficos
Publicado no:Shock
Main Authors: Phares, Timothy W., Kotraiah, Vinayaka, Chung, Chun-Shiang, Unsinger, Jacqueline, Mazer, Monty, Remy, Kenneth E., Browne, Cecille D., Buontempo, Peter, Mansour, Marc, Pannucci, James, Ayala, Alfred, Hotchkiss, Richard S., Gutierrez, Gabriel M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8284559/
https://ncbi.nlm.nih.gov/pubmed/33065715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/SHK.0000000000001682
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