Novel Peptide-Based PD1 Immunomodulators Demonstrate Efficacy in Infectious Disease Vaccines and Therapeutics

Many pathogens use the same immune evasion mechanisms as cancer cells. Patients with chronic infections have elevated levels of checkpoint receptors (e.g., programed cell death 1, PD1) on T cells. Monoclonal antibody (mAb)-based inhibitors to checkpoint receptors have also been shown to enhance T-ce...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Kotraiah, Vinayaka, Phares, Timothy W., Browne, Cecille D., Pannucci, James, Mansour, Marc, Noe, Amy R., Tucker, Kenneth D., Christen, Jayne M., Reed, Charles, MacKay, Alecia, Weir, Genevieve M., Rajagopalan, Rajkannan, Stanford, Marianne M., Chung, Chun-Shiang, Ayala, Alfred, Huang, Jing, Tsuji, Moriya, Gutierrez, Gabriel M.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7068811/
https://ncbi.nlm.nih.gov/pubmed/32210956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00264
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