Novel Peptide-Based PD1 Immunomodulators Demonstrate Efficacy in Infectious Disease Vaccines and Therapeutics

Many pathogens use the same immune evasion mechanisms as cancer cells. Patients with chronic infections have elevated levels of checkpoint receptors (e.g., programed cell death 1, PD1) on T cells. Monoclonal antibody (mAb)-based inhibitors to checkpoint receptors have also been shown to enhance T-ce...

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發表在:Front Immunol
Main Authors: Kotraiah, Vinayaka, Phares, Timothy W., Browne, Cecille D., Pannucci, James, Mansour, Marc, Noe, Amy R., Tucker, Kenneth D., Christen, Jayne M., Reed, Charles, MacKay, Alecia, Weir, Genevieve M., Rajagopalan, Rajkannan, Stanford, Marianne M., Chung, Chun-Shiang, Ayala, Alfred, Huang, Jing, Tsuji, Moriya, Gutierrez, Gabriel M.
格式: Artigo
語言:Inglês
出版: Frontiers Media S.A. 2020
主題:
Immunology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7068811/
https://ncbi.nlm.nih.gov/pubmed/32210956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00264
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