Bridging Computational Vaccinology and Vaccine Development Through Systematic Identification, Characterization, and Downselection of Conserved and Variable Circumsporozoite Protein CD4 T Cell Epitopes From Diverse Plasmodium falciparum Strains

An effective malaria vaccine must prevent disease in a range of populations living in regions with vastly different transmission rates and protect against genetically-diverse Plasmodium falciparum (Pf) strains. The protective efficacy afforded by the currently licensed malaria vaccine, Mosquirix™, p...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Noe, Amy R., Terry, Frances E., Schanen, Brian C., Sassano, Emily, Hindocha, Pooja, Phares, Timothy W., Moise, Leonard, Christen, Jayne M., Tucker, Kenneth D., Kotraiah, Vinayaka, Drake, Donald R., Martin, William D., De Groot, Anne S., Gutierrez, Gabriel M.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8217813/
https://ncbi.nlm.nih.gov/pubmed/34168657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.689920
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