Piperidine-4-Carboxamides Target DNA Gyrase in Mycobacterium abscessus

New, more-effective drugs for the treatment of lung disease caused by nontuberculous mycobacteria (NTM) are needed. Among NTM opportunistic pathogens, Mycobacterium abscessus is the most difficult to cure and intrinsically multidrug resistant. In a whole-cell screen of a compound collection active a...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Antimicrob Agents Chemother
Prif Awduron: Negatu, Dereje Abate, Beuchel, Andreas, Madani, Abdeldjalil, Alvarez, Nadine, Chen, Chao, Aragaw, Wassihun Wedajo, Zimmerman, Matthew D., Laleu, Benoît, Gengenbacher, Martin, Dartois, Véronique, Imming, Peter, Dick, Thomas
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2021
Pynciau:
Mechanisms of Action: Physiological Effects
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8284461/
https://ncbi.nlm.nih.gov/pubmed/34001512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00676-21
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