TBAJ-876, a 3,5-Dialkoxypyridine Analogue of Bedaquiline, Is Active against Mycobacterium abscessus

Lung disease caused by Mycobacterium abscessus is very difficult to cure, and treatment failure rates are high. The antituberculosis drug bedaquiline (BDQ) is used as salvage therapy against this dreadful disease. However, BDQ is highly lipophilic, displays a long terminal half-life, and presents a...

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Bibliografiset tiedot
Julkaisussa:Antimicrob Agents Chemother
Päätekijät: Sarathy, Jickky Palmae, Ganapathy, Uday S., Zimmerman, Matthew D., Dartois, Véronique, Gengenbacher, Martin, Dick, Thomas
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2020
Aiheet:
Experimental Therapeutics
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7179298/
https://ncbi.nlm.nih.gov/pubmed/31964791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02404-19
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