3,5-Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel

Bedaquiline is a new drug of the diarylquinoline class that has proven to be clinically effective against drug-resistant tuberculosis, but has a cardiac liability (prolongation of the QT interval) due to its potent inhibition of the cardiac potassium channel protein hERG. Bedaquiline is highly lipop...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem
Main Authors: Sutherland, Hamish S., Tong, Amy S.T., Choi, Peter J., Blaser, Adrian, Conole, Daniel, Franzblau, Scott G., Lotlikar, Manisha U., Cooper, Christopher B., Upton, Anna M., Denny, William A., Palmer, Brian D.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6467547/
https://ncbi.nlm.nih.gov/pubmed/30803745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2019.02.026
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